The molecule that
rewired appetite.
An independent, data-driven reading room for semaglutide — every trial, every price, every provider, sourced from the FDA, NIH and CMS. No affiliates. No promotions.
What it is, plainly.
Semaglutide is a long-acting analogue of glucagon-like peptide-1, a hormone the gut secretes after a meal. By binding the GLP-1 receptor for roughly a week per injection, it slows gastric emptying, sharpens insulin response and dampens the brain's drive to eat. The compound was first approved for type-2 diabetes in 2017, then for chronic weight management in 2021, and most recently — after the 17,604-patient SELECT trial — for cardiovascular risk reduction in adults with obesity and established heart disease.
What follows is not a sales page. It is a reference. Six chapters, one drug, every claim sourced. Use the formulary to compare what you can actually buy. Use the evidence section to read the trials in plain language. Use the pricing tool to understand what an honest cash price looks like in your pharmacy.
Mean body weight reduction at week 68 in STEP-1 (n=1,961), 2.4 mg semaglutide vs −2.4% on placebo.
Reduction in major adverse cardiovascular events in SUSTAIN-6 over 104 weeks.
Patients enrolled in SELECT, the trial behind the 2024 cardiovascular indication.
Plasma half-life — the reason a single subcutaneous injection lasts a week.
Five chapters. One drug. Read in any order.
Each section is rebuilt nightly from the FDA Drug API, ClinicalTrials.gov, CMS Part D filings and a panel of pharmacy feeds. We never recommend — we surface evidence and let you decide.
- 01FormularyBrand · Generic · Compounded
Wegovy, Ozempic, Rybelsus and the 503A landscape — side by side, with FDA status, indications and notes.
- 02EvidenceSTEP · SUSTAIN · PIONEER · SELECT
Every primary and secondary endpoint, summarized in plain English. Cohort sizes, duration, results.
- 03Titration0.25 → 2.4 mg, week by week
An interactive escalation schedule with side-effect mitigation and missed-dose logic.
- 04PricingCash · Coupon · Part D
Live pharmacy cash prices, GoodRx index, manufacturer savings cards and Medicare tiering.
- 05ProvidersTelehealth · In-person
Verified clinics filtered by state, accepted insurance, wait time and consultation price.
The titration matters more than the dose.
Most adverse events — nausea, fatigue, injection-site reaction — concentrate in the first four weeks of escalation. Patients who follow the 16-week titration schedule report dramatically lower rates of discontinuation than those who jump to the maintenance dose early.
Open the titration guide →The honest answer is: it depends.
Wegovy's list price is $1,349 per month. Most patients with commercial insurance pay between $25 and $200. Most patients without coverage pay the list price unless they qualify for the manufacturer savings card. Compounded versions, while not FDA-approved, range from $199 to $450.
Open the pricing tool →
Stop scrolling forums. Start with the literature.
Set in Instrument Serif and Inter. Composed in New York. Updated nightly from public datasets. Not affiliated with Novo Nordisk, any compounding pharmacy, or any telehealth platform.